Ultrastructural changes produced in rheumatoid synovial membrane by chrysotherapy.

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Ultrastructural changes produced in rheumatoid synovial membrane by chrysotherapy.

Biopsies of rheumatoid synovial membrane before and after chrysotherapy were examined with the light and electron microscopes, and subjected to electronprobe x-ray analysis. The main change noted was the occurrence of electron-dense deposits of characteristic morphology within pre-existing lysosomes. Such deposits were also seen in other varieties of lysosomal bodies. X-ray analysis showed the ...

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hypersensitivity in rheumatoid arthritis reversed by chrysotherapy

A prospective 24 week study of 31 patients with active rheumatoid arthritis (18 women, 13 men) was undertaken to determine whether weekly intramuscular sodium aurothiomalate (gold) would influence delayed type cutaneous hypersensitivity (DTH) and other indices of cell mediated immunity. DTH to seven recall antigens was measured by Multitest on three occasions during the study. Twenty five patie...

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Synovial membrane in experimentally-produced chronic haemarthrosis.

The gross and light microscopical changes that occur in the synovial membrane in human chronic haemarthrosis are well documented (Key, 1932; Ghormley and Clegg, 1948; Collins, 1951; De Palma and Cotler, 1956; Rodnan, Brower, Hellstrom, Didisheim, and Lewis, 1959) and virtually every change seen in man has been reproduced in the experimental animal (Key, 1929; Young and Hudacek, 1954; Wolf and M...

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In vitro synthesis of immunoglobulin by rheumatoid synovial membrane.

A technique for the in vitro culture of rheumatoid synovial tissue with (14)C-amino acids and isolation and quantitation of the newly synthesized immunoglobulins has been developed. This technique has been used to compare immunoglobulin synthesis of 12 rheumatoid synovia with that of synovia from nonarthritic patients and with that of normal human lymph nodes and spleen. In addition, the spleen...

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Chrysotherapy in the Treatment of Rheumatoid Arthritis

THIS paper is based on a two-years experience in the treatment of arthritis by gold salts. Of the twenty-seven patients treated, thirteen were typical cases of rheuma-toid arthritis.Thirteen others were considered to be examples of climacteric arthritis. Their joint condition resembled that of the rheumatoid cases, but was associated with endocrine disturbances of the menopause. The tast case w...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1976

ISSN: 0003-4967

DOI: 10.1136/ard.35.1.67